Understanding Neuropathic Pain: Causes, Symptoms, and Treatment Options
A comprehensive overview of nerve pain (neuropathic pain), what causes it, how it feels, and the evidence-based treatments available at Cygnet Clinic, Fremantle.
What Is Neuropathic Pain?
Neuropathic pain, often called nerve pain, is pain caused by damage to or dysfunction of the nervous system itself. Unlike nociceptive pain (the pain you feel from a cut, burn, or sprain, which comes from tissue damage), neuropathic pain arises from the nerves that detect and transmit pain signals. This makes it a fundamentally different type of pain that often requires different treatment approaches.
Neuropathic pain is estimated to affect approximately 7 to 10 per cent of the population and is a significant contributor to chronic pain disability.
Common Causes of Neuropathic Pain
Neuropathic pain can result from a wide range of conditions, including:
- Diabetic neuropathy: High blood sugar levels over time damage peripheral nerves, most commonly in the feet and legs. This is one of the most common causes of neuropathic pain.
- Post-herpetic neuralgia: Nerve pain that persists after a shingles outbreak. The varicella-zoster virus damages nerve fibres, causing pain that can last for months or years.
- Sciatica and radiculopathy: Compression or inflammation of a spinal nerve root, often from a herniated disc, causing pain to radiate down the leg or arm.
- Nerve injury or entrapment: Trauma, surgery, or compression (such as carpal tunnel syndrome) can damage peripheral nerves.
- Complex Regional Pain Syndrome (CRPS): A complex condition causing severe, burning pain, swelling, and sensitivity in a limb, often following an injury.
- Chemotherapy-induced peripheral neuropathy: Certain chemotherapy drugs can damage peripheral nerves.
- Trigeminal neuralgia: Severe, shock-like facial pain caused by irritation of the trigeminal nerve.
- Alcohol-related neuropathy: Long-term excessive alcohol consumption can damage nerves.
- Multiple sclerosis and other central nervous system conditions.
How Does Neuropathic Pain Feel?
Neuropathic pain has distinctive characteristics that set it apart from other types of pain. Patients often describe it as:
- Burning: A hot, searing sensation, often in the feet or hands
- Shooting or electric shock-like: Sudden, sharp, lancinating pains
- Tingling or pins and needles (paraesthesia)
- Numbness: A loss of sensation in the affected area
- Allodynia: Pain from stimuli that should not be painful, such as light touch or clothing against the skin
- Hyperalgesia: An exaggerated pain response to a normally painful stimulus
If you experience any of these symptoms, it is important to discuss them with your GP, who can assess whether a referral to a pain specialist is appropriate.
How Is Neuropathic Pain Diagnosed?
Diagnosis begins with a thorough clinical history and neurological examination. Dr Agrawal will assess the location, quality, and triggers of your pain, perform a physical and neurological examination, and review any relevant investigations such as nerve conduction studies, MRI scans, or blood tests. Identifying the underlying cause is essential, as this guides the treatment approach.
Treatment Options for Neuropathic Pain
Neuropathic pain often requires a multimodal approach, as it tends not to respond as well to standard painkillers (such as paracetamol or ibuprofen) as nociceptive pain does. Treatment options include:
Medication
- Neuromodulatory medications: Certain medications originally developed for epilepsy or depression are highly effective for neuropathic pain. These include gabapentin, pregabalin, duloxetine, and amitriptyline. They work by modulating how nerves transmit pain signals.
- Topical treatments: Lidocaine patches, capsaicin cream, or compounded topical preparations can be effective for localised nerve pain.
- Opioids: Generally used cautiously and as a last resort, as neuropathic pain often responds poorly and the risks of long-term opioid use are significant.
Interventional Procedures
- Nerve blocks: Targeted injections of local anaesthetic near specific nerves can provide diagnostic information and therapeutic relief.
- Epidural steroid injections: For nerve root pain (sciatica, radiculopathy) caused by spinal conditions.
- Spinal cord stimulation: An advanced neuromodulation therapy for severe, refractory neuropathic pain that has not responded to other treatments. Electrode leads are placed in the epidural space to deliver mild electrical pulses that modulate pain signals.
- Radiofrequency ablation: For certain nerve pain conditions, controlled heat can disrupt the targeted nerve's ability to transmit pain.
Multidisciplinary Support
- Cognitive behavioural therapy (CBT): Helps reframe the relationship between mind and persistent pain, reducing the impact of pain on daily life.
- Graded exercise and physiotherapy: Maintains function and prevents the deconditioning that often accompanies chronic nerve pain.
- Sleep optimisation: Neuropathic pain often disrupts sleep, and poor sleep amplifies pain. Addressing sleep is a critical component of treatment.
Seeking Help for Neuropathic Pain in Perth
If you are experiencing burning, shooting, or tingling pain that may be neuropathic, ask your GP for a referral to Dr Ravi Agrawal at Cygnet Clinic, 109 Marine Terrace, Fremantle WA 6160. A comprehensive assessment can identify the cause of your pain and guide an evidence-based, individualised treatment plan.