Complex Regional Pain Syndrome (CRPS): Symptoms, Diagnosis, and Treatment
A patient guide to CRPS, a complex chronic pain condition, covering early signs, diagnosis, and the multidisciplinary treatment approach at Cygnet Clinic.
What Is Complex Regional Pain Syndrome?
Complex Regional Pain Syndrome (CRPS) is a chronic pain condition that most often affects a limb (arm, leg, hand, or foot) after an injury, surgery, stroke, or heart attack. It is characterised by severe, persistent pain that is disproportionate to the severity of the initial injury. CRPS is relatively rare, but when it occurs, it can be profoundly debilitating.
CRPS was previously known as Reflex Sympathetic Dystrophy (RSD) and is sometimes still referred to by that name. There are two types:
- CRPS Type 1: Occurs after an illness or injury that did not directly damage a nerve. This is the more common type, accounting for approximately 90 per cent of cases.
- CRPS Type 2: Occurs after a direct, confirmed nerve injury.
Both types share the same symptoms and treatment approach.
What Causes CRPS?
The exact cause of CRPS is not fully understood, but it is believed to involve a malfunction in the central and peripheral nervous systems. After an injury, the inflammatory and nervous system responses that normally promote healing become dysregulated, leading to persistent pain, swelling, and changes in skin temperature and colour.
CRPS can develop after:
- Fractures (particularly wrist and ankle fractures)
- Sprains and soft tissue injuries
- Surgery
- Crush injuries
- Stroke or heart attack
- In some cases, no obvious trigger is identified
Early Signs and Symptoms of CRPS
Early recognition and treatment of CRPS is critical, as outcomes are generally better when treatment begins early. The key signs and symptoms include:
- Severe, burning or throbbing pain: Disproportionate to the initial injury, often affecting most of the limb rather than just the injury site.
- Sensitivity (allodynia): The affected skin becomes extremely sensitive to touch, even light touch from clothing or a breeze.
- Swelling: The affected limb may become swollen and puffy.
- Changes in skin temperature: The limb may feel warmer or cooler than the opposite limb.
- Changes in skin colour: The skin may appear red, purple, blotchy, or pale.
- Changes in skin texture: The skin may become shiny, thin, or excessively sweaty.
- Changes in nail and hair growth: Nails may grow faster or slower; hair growth patterns may change.
- Joint stiffness and reduced range of motion: Particularly in the fingers and toes.
- Muscle weakness and loss of function: Difficulty moving the affected limb.
If you experience these symptoms after an injury or surgery, it is important to seek medical assessment promptly.
How Is CRPS Diagnosed?
There is no single test for CRPS. Diagnosis is based on clinical assessment using the Budapest Criteria, which require:
- Continuing pain that is disproportionate to the inciting event
- At least one symptom reported in each of four categories: sensory (hyperaesthesia or allodynia), vasomotor (temperature or colour changes), sudomotor/oedema (swelling or sweating changes), and motor/trophic (reduced range of motion, weakness, tremor, or changes in hair, skin, or nails)
- At least one sign observed in two or more of these categories at the time of assessment
- No other diagnosis that better explains the signs and symptoms
Dr Agrawal will conduct a thorough clinical assessment and may order tests (such as bone scans, nerve conduction studies, or X-rays) to exclude other conditions.
Treatment Approach for CRPS
CRPS requires early, multidisciplinary intervention. The goals of treatment are to reduce pain, restore function, and prevent progression. Treatment is most effective when started within the first few months of symptom onset.
1. Physical and Occupational Therapy
This is the cornerstone of CRPS treatment. Graded, gentle exercises to maintain joint mobility, improve strength, and restore function are essential. A physiotherapist or occupational therapist experienced in CRPS management will design a program that progresses gradually, desensitising the affected limb and rebuilding confidence in movement.
2. Medication
- Neuropathic pain medications: Gabapentin, pregabalin, amitriptyline, and duloxetine can help reduce nerve-related pain.
- Anti-inflammatories: NSAIDs may help reduce inflammation in early CRPS.
- Topical agents: Lidocaine patches or compounded creams for localised pain.
- Bisphosphonates: In some cases, these medications (which affect bone metabolism) may be used.
3. Interventional Procedures
- Sympathetic nerve blocks: Stellate ganglion blocks (for upper limb CRPS) or lumbar sympathetic blocks (for lower limb CRPS) can provide significant pain relief and improve blood flow to the affected limb. These blocks target the sympathetic nervous system, which is thought to play a role in CRPS.
- Spinal cord stimulation: For severe, refractory CRPS that has not responded to other treatments, spinal cord stimulation can be highly effective. A trial period is conducted first, and if successful (at least 50 per cent pain reduction), a permanent device is implanted.
- Intrathecal drug delivery: In rare, severe cases, implanted pumps deliver medication directly to the spinal fluid.
4. Psychological Support
- Cognitive behavioural therapy (CBT): Helps manage the psychological impact of chronic pain, reduce fear-avoidance behaviour, and improve coping strategies.
- Graded motor imagery (GMI): A specialised rehabilitation technique that retrains the brain's representation of the affected limb through a sequence of left/right discrimination, imagined movements, and mirror therapy.
5. Multidisciplinary Coordination
At Cygnet Clinic, Fremantle, Dr Agrawal works closely with physiotherapists, psychologists, and other allied health professionals to provide coordinated, holistic care for CRPS patients. Regular follow-up allows treatment to be adjusted based on your response.
Prognosis and Recovery
With early, appropriate treatment, many CRPS patients experience significant improvement or remission. However, recovery can be slow, taking months rather than weeks. Some patients may have persistent symptoms requiring ongoing management. The key message is that CRPS is treatable, and early intervention gives the best chance of a good outcome.
If you or someone you know is experiencing symptoms of CRPS, ask your GP for a prompt referral to Dr Ravi Agrawal at Cygnet Clinic, 109 Marine Terrace, Fremantle WA 6160.